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The protozoan diseases leishmaniasis, Chagas' disease and African trypanosomiasis are major health problems in many countries, particularly developing countries, and there are few drugs available to treat these diseases. Dihydrofolate reductase (DHFR) inhibitors have been used successfully in the treatment of a number of other diseases such as cancer, malaria and bacterial infections; however they have not been used for the treatment of these diseases. This article summarises studies on leishmanial and trypanosomal DHFR inhibitor development and evaluation. Possible mechanisms of resistance to DHFR inhibitors are also discussed. Kin selection theory predicts that people should invest more Mbt Shoes Toronto Ontario in their full than their half siblings, and more in their nieces and nephews via full siblings than via half siblings. To study these predictions we use two nationally representative surveys that were collected as a part of the Generational Transmissions in Finland project. The subjects are representative Buy Mbt Shoes Vancouver Canada of an older generation (born in 1945–1950) and a younger generation (born in 1962–1993). We found that both generations reported more contacts with full than with half siblings, and more with nieces and nephews via full than half siblings respectively. The results of the study are in line with the kin selection theory.
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